Clinical Evidence Library

Independent clinical and laboratory research on aligner and retainer cleansing, oral appliance hygiene, and advanced cleaning technologies.

Oral Appliance Cleansing Performance

In Vitro Study

Biofilm removal efficacy of a cleansing/disinfecting tablet formulation.

Ghent University • 2008

In vitro laboratory study using a modified Robbins device (biofilm model).

This laboratory study demonstrated significant biofilm reduction, showing high activity against organisms such as Candida albicans and Staphylococcus aureus under controlled conditions.

In Vitro Study

Sanitization effectiveness of denture cleansing tablets against microbial contamination.

Oklahoma State University Cente • 2004

In vitro microbiological evaluation.

A single application of cleansing tablets effectively eliminated selected microorganisms, including Candida albicans, Staphylococcus aureus, and certain viruses in vitro.

Clinical Trial

Effect of cleansing tablets on Candida levels in removable orthodontic appliances.

Mater Dei Hospital & University of Malta, with MSI Laboratories. • 2012

Participants using the cleansing formulation showed a reduction trend in Candida burden, while the control group demonstrated increased colonization.

Effect of cleansing tablets

In Vitro Study

Antimicrobial effects of effervescent cleansing tablets

Ribeirão Preto School of Dentistry, University of São Paulo (Brazil) • 2020

Results indicated moderate antimicrobial action, with measurable reductions in specific microorganisms depending on the cleansing solution tested.

Randomized clinical study

Biofilm removal and antimicrobial efficacy of cleansing tablets in denture wearers.


University of São Paulo (Brazil), MSI Laboratories collaboration. • 2010

The experimental group exhibited significantly lower denture biofilm levels and reduced yeast counts compared to brushing alone.

In Vitro Study

Antimicrobial effects of alkaline peroxide cleansers on biofilms.

University of São Paulo (Brazil). • 2016

The tested cleansing tablet demonstrated superior antimicrobial activity against multiple microorganisms compared with alternative cleansers.

Controlled Trial

Reduction of plaque accumulation and odor in orthodontic appliance wearers.

University of Malta & MSI Laboratories. • 2011

Use of cleansing tablets significantly reduced plaque buildup and improved appliance odor compared with placebo.